The primary benefit expected from UCART123 for participating patients is a high degree of T-cell expansion that could induce high and sustained anti-CD123 activity, leading to durable remission in poor-prognosis patients with AML.Also, patients are expected to benefit from the immediate availability of UCART123 cells and the higher, more homogenous transduction success rate expected from healthy allogeneic cells, compared to autologous T-cells.
The absence of cell-surface expression of the TCR complex on UCART123 eliminates the TCR-recognition of histocompatibility antigens, the primary mechanism of GVHD, and confers a "universal" character to UCART123, which circumvents the necessity of human leukocyte antigen (HLA) matching between donor and recipient.
Phase I, Open Label Dose Escalation and Dose Expansion Study to Evaluate the Safety, Expansion, Persistence, and Clinical Activity of a Single Dose of UCART123 (Allogeneic Engineered T Cells Expressing Anti-CD123 Chimeric Antigen Receptor), Administered in Patients With Relapsed/Refractory Acute Myeloid Leukemia, and Patients With Newly Diagnosed High-risk Acute Myeloid Leukemia A single IV administration of UCART123 in the dose escalation phase will explore 3 doses of UCART123 ranging from 6.25x10^5 cells/kg to 6.25 x10^6 cells/kg and continue until the Recommended Phase 2 Dose (RP2D) is identified.
It has been well known instrument internationally for two decades. Authors Matthias Jerusalem & Ralf Schwarzer, 1992 Reliability and Validity Cronbach’s alphas ranging from .76 to .90 Obtaining the GSES The scale is available in 30 languages here.
FAQ Page Administration, Analysis and Reporting Statistics Solutions consists of a team of professional methodologists and statisticians that can assist the student or professional researcher in administering the survey instrument, collecting the data, conducting the analyses and explaining the results. Self-efficacy as a resource factor in stress appraisal processes. Schwarzer (Ed.), Self-efficacy: Thought control of action (pp.
The Program is developed in successive steps that tailor the intervention to the developmental level of children. Besides classrooms activities, the Program is reinforced by involving teachers, families and the school environment to reach the children’s immediate circles.
Strategies and materials are also adapted to the compulsory curriculum of the school. Teachers receive formal training, a teaching guide, and have access to all the materials and resources available on the SI! During the intervention, families receive instructions for home activities and key messages about their children’s health. Adaptation and validation of an Estonian version of the General Self-Efficacy Scale (ESES). Scholz, U., Gutiérrez-Doña, B., Sud, S., & Schwarzer, R. Paper presented at the First Asian Congress of Health Psychology: Health Psychology and Culture, Tokyo, Japan. Cross-Cultural Assessment of Coping Resources: The General Perceived Self-Efficacy Scale. Program promotes cardiovascular health through a multilevel school-based intervention on four lifestyle-related components: diet, physical activity, understanding the body and heart, and management of emotions.The final KAH-questionnaire for elementary school children should be administered to children individually by trained staff.